AB0881 CLINICAL TRAJECTORIES OF MULTIFACTORIAL HAND FUNCTION DETERIORATION IN SYSTEMIC SCLEROSIS

Background Hand function deterioration is a major multifactorial driver of disability in Systemic Sclerosis (SSc) whose rate has been poorly described. Objectives The aim this study to describe incidence and risk factors hand functional worsening longitudinal, multicenter, observational SSc cohort. Methods involvement were evaluated consecutively enrolled patients for 24 months. Patient-reported impairment was captured with Cochin Disability Score (CHFS) the corresponding minimal clinical important differences (MCID) patient acceptable symptom state (PASS). Clinical association CHFS change over time clinically meaningful (MCID-Worsening) investigated. Results Three-hundred-ninety-six from 10 centres 201 (age 55.7±12.2 years, male 13.4%) included final analysis. Median (IQR) disease duration 5 (2-11) years while proportion diffuse cutaneous variant 29.9%. Fifty-six (27.8%) had ≥PASS at baseline. increased 35.8% reaching CHFS≥PASS (p<0.001), 52.2% reporting MCID-Worsening A LASSO model simultaneously exploring effects multiple baseline variables showed that associated gender, LeRoy variant, late capillaroscopy pattern, shorter duration, absence digital ulcers, presence tenosynovitis, pain, Raynaud’s phenomenon, global severity, together treatment immunosuppressants, vasoactive medications, second-line analgesics. Conclusion tends deteriorate one two despite available therapies assessment support stratification. These results pave way inform design intervention studies aimed improving outcome SSc. REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.